Forensic y-str study in y-chromosome abnormalities

Abstract

Y-chromosome infertility is usually caused by deletions of genetic material in Azoospermia Factor (AZF) regions, localized in three nonoverlapping Yq regions – AZFa, AZFb and AZFc. However, some of the Y-ST Rs routinely studied in Forensic Genetics with multiplex kits are localized in these three regions giving rise to microdeletions observed in some loci. Rare alleles were also encountered in these samples with Y-chromosome structural changes. A complete Y-ST R profile in a sample from a female individual was detected which may raise ethical implications. The aim of this work is to assess the validity in the use of Y-ST R multiplex systems in structurally abnormal Y-chromosomes, which may occur in forensic casework analysis